Polysialic acid enhances the migration and invasion of human cytotrophoblasts
نویسندگان
چکیده
منابع مشابه
Polysialic acid enhances the migration and invasion of human cytotrophoblasts.
Polysialic acid (polySia) is a large, cell-surface linear homopolymer composed of α2,8-linked sialic acid residues. Most extensively studied in the nervous system, this unique glycan modulates development by enhancing cell migration and regulating differentiation. PolySia also functions in developing and adult immune systems and is a signature of many cancers. In this study, we demonstrated tha...
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The specialized interaction between embryonic and maternal tissues is unique to mammalian development. This interaction begins with invasion of the uterus by the first differentiated embryonic cells, the trophoblasts, and culminates in formation of the placenta. The transient tumor-like behavior of cytotrophoblasts, which peaks early in pregnancy, is developmentally regulated. Likewise, in cult...
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چکیده ندارد.
15 صفحه اولRole of human cytomegalovirus in the proliferation and invasion of extravillous cytotrophoblasts isolated from early placentae.
AIM We investigated the role of human cytomegalovirus (HCMV) and its mechanism in extravillous cytotrophoblast (EVT) proliferation and invasion in vitro. METHODS Differential enzymatic digestion combined with gradient centrifugation, was used to isolate primary EVT from human chorionic villi collected from early placentae of healthy pregnant women. HCMV infection was determined by immunofluor...
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Lysophosphatidic acid (LPA) is both a potential marker and a therapeutic target for ovarian cancer. It is critical to identify the sources of elevated LPA levels in ascites and blood of patients with ovarian cancer. We show here that human peritoneal mesothelial cells constitutively produce LPA, which accounts for a significant portion of the chemotactic activity of the conditioned medium from ...
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ژورنال
عنوان ژورنال: Glycobiology
سال: 2012
ISSN: 1460-2423,0959-6658
DOI: 10.1093/glycob/cws162